Skin damages due to trauma, burns and skin diseases can compromise the vital skin functions (such as, thermoregulation, excretion, absorption, as well as physical and immunological barrier function), leading to morbidity and mortality of the patient. Especially for large skin defects, if they are not treated in an effective manner, a large amount of body fluids will be lost, which will seriously threaten the patients’ life. The next generation of tissue engineered constructs need to be driven by a personal medicine approach and must integrate biological and physical properties for optimal skin reconstruction. In this context the main concept of the project is to design of new 3D bio-inspired hybrid architectures for skin repair and regeneration. The project will provide bioactive architectures and compositions starting from polymeric mixtures, hydrogels and complex 3D structures. The proposed hybrid materials have potential clinical application as artificial/bioartificial materials and can be loaded with biological agents, which are released in specific environment. Initian TRL level correspond to the level TRL2 (technology concept formulated) and at the end level TRL4 (3D hybrid bioscaffold is demonstrated in defined conditions for regenerative medicine). Objectives of the project: to prepare and evaluate the 3D biomimetic scaffolds able to respond to biological stimuli (scientific impact); Sustainable technology for 3D hybrid scaffolds (technological impact); new therapy based on in vitro and in vivo tests (economic impact); Qualification of human resources by stimulation of professional training (social impact).